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The term describes facial hollowing, looser skin, deeper folds, and a more aged appearance that can become noticeable after substantial weight loss on semaglutide, tirzepatide, or another GLP-1 medication

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However, it is important to be cautious here: these are not head-to-head trials , and patient populations, trial durations, and protocols differ

[62] Research continued, and in 1993, Michael Nauck managed to infuse GLP-1 into people with type 2 diabetes, stimulating insulin while inhibiting glucagon and bringing blood glucose to normal levels