What Do We Know About GLP-1s in Pregnancy
Key weight loss results at 48 weeks by group: Response rates at 48 weeks (12 mg dose): 100% achieved greater than or equal to 5% weight loss 93% achieved greater than or equal to 10% weight loss 83% achieved greater than or equal to 15% weight loss The cardiometabolic improvements were also significant, with reductions in blood pressure, triglycerides, LDL cholesterol, HbA1c, fasting glucose, and fasting insulin across all dose groups
GIP and GLP-1 effects on gastric emptying The secretion of endogenous GIP does not correlate with gastric half-emptying times (150)
doi: 10.1056/NEJMoa2407379 21 AronneLJHornDBle RouxCWHoWFalconBLValderasEGet al
(iii) Not Routinely Recommended: emphasizes lifestyle intervention and first-line OI where appropriate, to avoid unnecessary exposure when metabolic burden is low and fertility urgency is high
Pharmacokinetically, these drugs are built for once-weekly dosing with long half-lives, so lower weekly doses really do produce lower overall exposure
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