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investigated the effects of TMAO on glucose tolerance in high fat diet (HFD)-fed mice, they found that dietary TMAO exacerbates impaired glucose tolerance, blocks the insulin signaling pathway in the liver, and led to adipose tissue inflammation in mice ( Recently, a clinical study conducted by found that in obese patients, there is a positive correlation between TMAO levels and MAFLD histologic features

Nature 404:652660 Moran TH, Dailey MJ (2011) Intestinal feedback signaling and satiety

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