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Over time, chronic inflammation can persist behind a repaired BBB, especially in progressive MS, but the initial establishment of neuroinflammation requires BBB disruption and infiltration

Adverse events with gastrointestinal symptoms were observed in 37.1%43.6% of patients in the tirzepatide group and 20.4% of patients in the placebo cohort

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Progress in Lipid Research

For a detailed breakdown of potential risks and safety considerations, visit the Ozempic safety page or the Metformin safety page