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32 Approximately 30% of patients present with extracutaneous involvement such as arthralgias or renal, gastrointestinal, pulmonary, or neurologic symptoms

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The effects of Ex-4 were reversed by the intervention of GLP-1R siRNA or Dorsomorphin, respectively

Enhancement of heat tolerance by 5-oxp could be associated with the up-regulation or activation of sugar and organic acid metabolism during photosynthesis and respiration, amino acid metabolism for protein synthesis, and the maintenance of nucleotide metabolism for ATP, DNA, and RNA synthesis (Fig8)

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