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Patients with diabetes may require alternative glucose management strategies during the interruption period

Generic Wegovy and Rybelsus are further out due to additional patents

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Moreover, one recent study (119) showed that lixisenatide exerted neuroprotection potentially by downregulating levels of NF-B, TLR2/4, MPO, and pP38 as well as upregulating expression of pERK1/2

Safety is unknownand potentially problematic

We applied these proportions to the most recent (2023) mid-year population estimates for Great Britain [39] to approximate the number of adults using these medications in 2024 and the number who would be interested in using them in the next year