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The CARS level correlates positively with PD-L1 expression and may induce the trans-sulfur pathway, leading to cysteine deprivation and ferroptosis inhibition (103)

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Crystals trigger inflammasome activation 4,7,8,9 mainly through frustrated phagocytosis, a process characterized either by aberrant actin polymerization 10 or by lysosomal damage 11 , in which lysosome contents leak into the cytosol