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Tirzepatide is a synthetic peptide currently under clinical trials

It may, however, increase the likelihood of side effects

Methods 13 , 883889 (2016)

Often without accounting for bioavailability differences between intraperitoneal (animal studies) and subcutaneous (human application) routes

This resistance reflects legitimate concerns about diagnostic accuracy but may also represent comfort with familiar approaches and reluctance to accept responsibility for uncertain diagnoses (Duffy et al., 2014)

For TB-500, the agency has said it has identified no human exposure data for drug products containing the peptide and also highlighted potential risks associated with aggregation and impurities