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Moreover, phospho-BCL-XL (Ser62) stabilizes G2 arrest by binding to and co-localizing with Cdk1 (cdc2) in nucleolar structures to avoid rapid nucleolar disassembly associated with mitosis onset, playing an unexpected role in the G2 phase checkpoint downstream of DNA damage distinct from its anti-apoptotic function 22
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Like other transmembrane proteins, SLC7A11 protein is synthesized in endoplasmic reticulum (ER) and subsequently transferred to the Golgi apparatus by vesicular and ultimately functions on the cell membrane [20]
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