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In practice, the majority of SubQ vs IM peptide research published in peer-reviewed literature reports subcutaneous administration as the primary route for systemic peptide delivery

Indeed, after 48 weeks on dulaglutide, patients showed a markedly different community structure compared to baseline, with certain bacterial populations decreasing in relative abundance while others increased, indicating that sustained GLP-1 RA therapy can reshape the gut microbiota over time (38)