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MurataAHyogoHNonakaMSumiokaASuehiroYFurudoiAet al

3, 4 5.2 Hypoxic Conditions Cells shift their metabolic processes under hypoxic conditions to survive in environments with low oxygen

Resistance mechanisms, such as GPX4 upregulation, compensatory FSP1 activity, and the protective role of specific TME components (e.g., M2 macrophages and Tregs via GPX4 expression), limit the efficacy of ferroptosis

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R., Espinoza, L., Wood, T

The Singapore Health Sciences Authority approved its use under similar guidelines, requiring proper medical supervision and regular monitoring throughout treatment