Biological actions of GLP-1, source: reference [1] Evolution of GLP1 GLP-1RAs Currently, there are nine GLP-1RAs approved for marketing worldwide (Table 1), mainly for the treatment of diabetes and obesity, of which tirzepatide is a novel dual GLP-1RA/GIPR agonist
These trials are designed to further investigate the long-term safety, efficacy, and side effect profiles of retatrutide in diverse populations, including individuals with obesity, those overweight, with type 2 diabetes, obstructive sleep apnea, or osteoarthritis
a , Representative image of hM3Dq expression in the DVC (AP and NTS)
Developed by Eli Lilly, retatrutide simultaneously targets GLP-1, GIP, and glucagon receptors, setting it apart from existing licensed treatments such as semaglutide and tirzepatide
Retatrutide is not approved by the MHRA or EMA
Bottom Line + Next Step Choosing between tirzepatide and semaglutide depends on clinical priorities