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declares that he holds equity in Regenosine, a biotech start-up developing therapies for osteoarthritis, and CanFite Biopharma, that he has received grant support from AstraZeneca and Kairos Inc., and that he has a number of patents involving adenosine receptors and hepatic fibrosis, wound healing, bone regeneration and osteoarthritis

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In vitro experiments demonstrated that agrin treatment significantly downregulated PDGFR and claudin-5 expression in a blood-brain barrier co-culture model comprising human brain microvascular endothelial cells and pericytes, suggesting that agrin may induce pericyte death and impair the integrity of the blood-brain barrier

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That includes intake history, contraindication screen, body composition baseline, and indication specific labs when needed