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Abstract In the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes

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In the primary analysis using the trial product estimand, which evaluated participants who adhered to treatment, bodyweight decreased progressively in all active treatment groups over the 26-week period, without clear evidence of reaching a plateau

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Anyway, a state of relative insuficiency may persist for several months after the discontinuation of the therapy, so any stress that occurs in this period requires reinstituting corticosteorid therapy or dose increase

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