Current guidelines recommend discontinuing semaglutide at least 2 months before planned conception due to its long half-life
The drug primarily increases insulin secretion and decreases glucagon secretion in a glucose-dependent manner
The newsletter also covers: Podcast: How PBMs help manage drug costs and support access WellBridge: Digital health solutions with measurable outcomes Catch up on the latest insights for plan sponsors: #TrueCost redefines pharmacy pricing by anchoring pricing to industry benchmarks (NADAC & WAC) that more accurately reflect pharmacy acquisition cost so plan sponsors can get greater visibility into drug costs and drug-level rebate value
More recently, two studies have further quantitatively summarized the 1 H-MRS glutamate literature, a new meta-analysis (Nakahara et al
There have been several published studies since as least 2018 that expose the above risks associated with these medications: Liraglutide Effects on Upper Gastrointestinal Investigations: Implications Prior to Bariatric Surgery, July 2018, Modi et al
People who are on semaglutide (Novos Ozempic or Novos Wegovy) could consider switching to tirzepatide (Lillys Mounjaro or Lillys Zepbound)
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