Some patients benefit from starting B12 supplementation at the same time they begin semaglutide therapy, while others may only need it after 36 months of GLP-1 treatment
March 5, 2025
If symptoms persist despite regular oral supplementation, absorption may be limited
I packed on the lbs during lock down
doi: 10.1210/jcem.87.5.8628
What the evidence shows Consistency across studies: a systematic review spanning 36 studies from 1993 to 2024 found reliable evidence of structural and functional recovery across tendon, ligament, muscle, and bone injury models, with no adverse effects reported at any dose tested, a notably clean safety signal given the study volume (Vasireddi et al., 2025) A specific mechanism in tendon repair: preclinical work found BPC-157 upregulates growth hormone receptor expression in tendon fibroblasts specifically, pointing to a plausible pathway for its effects on connective tissue (Chang et al., 2018) Reach beyond the musculoskeletal system: research has extended into the gut, liver, and cardiovascular system, suggesting the cytoprotective activity isnt confined to one tissue type but reflects a broader mechanism (Jozwiak et al., 2025) For research use only
