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RF and SJ designed the studies

Apoptosis/necroptosis inhibitors Pan-caspase inhibitors Z-VAD-FMK block caspase-3/9, while RIPK3 inhibitors suppress necroptosis, reducing hepatocyte loss in animal models [40, 45]

Butyrate increases histone acetylation at promoter regions of inflammatory genes, thereby suppressing their transcription (Chang et al., 2014)

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The energy of the resulting structure was minimized utilizing AMBER14:EHT forcefield in MOE 72,73 with all the settings set default until the RMS gradient reached 0.001 kcal/mol/ 2