CagriSema's REDEFINE 1 number is competitive against tirzepatide's SURMOUNT-1 figure, but a direct head-to-head trial reported in February 2026 favored tirzepatide
However, the medication isnt recommended during pregnancy
In this trial, only vitamin E met the prespecified significance level of the primary outcome (i.e., improvement in histological findings, which included an improvement in hepatocellular ballooning), although both active treatment groups had a significant reduction in steatosis, lobular inflammation, and NAS (NAFLD activity score)
Common checks to discuss with your clinician include: CBC (screens for anemia) Ferritin and iron studies TSH (thyroid screening) Vitamin D Vitamin B12 Zinc is sometimes considered, but usually only if there is a clinical reason to suspect deficiency
For non-emergent but concerning symptoms (new rectal bleeding, persistent or recurrent bleeding, or blood plus changes in bowel habits), prompt evaluation within days is appropriate
Applicable Procedures Codes: J0222, J0225