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Hepatic Support and Detoxification The liver synthesizes and depends on glutathione more than any other organ

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DucaLOttolenghiSCoppolaSRinaldoRDei CasMRubinoFMet alDifferential redox state and iron regulation in chronic obstructive pulmonary disease, acute respiratory distress syndrome and coronavirus disease 2019

Mechanistically distinct from other forms of cell death, cuproptosis is characterized by the direct binding of copper to lipoylated enzymes in the mitochondrial tricarboxylic acid (TCA) cycle, leading to proteotoxic stress and subsequent cell death, independent of classical apoptotic signaling [3]

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[DOI] [PubMed] [Google Scholar] 144.Petkov V., Radomirov R