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Self-prescribing high-dose B12 without medical indication is inadvisable, particularly for individuals with underlying health conditions

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The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study

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(4) reduction of hepatic glucose output

For this reason, bacteriostatic water-diluted medications should be used during pregnancy only if clearly needed and if the potential benefit justifies any potential risk to the fetus