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also recently demonstrated that all eight NAFLD patients with SGLT2 administration relieved hepatic steatosis and three of them obtained improvement in liver fibrosis [47]

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2019;316:E895-907

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The first clinical candidate for a small-molecule GcgR antagonist was MK-0893 in which 80 mg daily treatment over 12-weeks demonstrated considerable efficacy in reducing fasted plasma glucose by 34% and HbA1c by 1.5% relative to placebo [74]

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