The answers that have emerged from decades of animal studies point to a compound with a genuinely unusual breadth of activity one that operates through multiple overlapping molecular mechanisms rather than a single, narrow pathway
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10.1089/dna.2019.50348 DNA Cell Biol
Journal Reference: Editorial Team, "FDA Grants Accelerated Approval for Sacituzumab Govitecan in Metastatic Triple-negative Breast Cancer", ADC Review (2020), FDA Press Release, "FDA grants accelerated approval to loncastuximab tesirine-lpyl for large B-cell lymphoma", (2021): Staudacher, Brown, "Antibody drug conjugates and bystander killing: is antigen-dependent internalisation required?", Br J Cancer 117, (2017): 1736-1742,
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