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ROS are reactive species that originate from incomplete reduction of oxygen with high chemical reactivity, including the hydroxyl radical, superoxide anion, and hydrogen peroxide ( Decades ago, Otto Warburg put forward that cancer cells depended on glycolysis to support cellular growth even under normoxic conditions (the so-called Warburg effect) ( High-throughput screening performed by the gain or loss-of-function studies in PC cells showed that the differentially expressed genes was partially related to the metabolic process and antioxidant activity

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doi: 10.1128/mBio.01636-14 148 Valles-ColomerM.FalonyG.DarziY.TigchelaarE

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POMC transcription is positively regulated by corticotrophin releasing hormone (CRH)