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There are several important limitations

Here are the most common ones: Nausea: This is the most common side effect, especially when starting the medication

To summarize these mechanisms and their corresponding efficacy with GLP-1RAs or GLP-1, GLP-1RAs show the endothelial protective properties and thus owe to modulating vascular tone and maintaining endothelial barrier integrity, as well as the anti-adhesive and anti-thrombotic actions

For researchers who respond well to retatrutide alone, the incremental benefit of adding cagrilintide must be weighed against these practical considerations

Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, et al

We manage this through appropriate informed consent, proper monitoring, and staying within our competency