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Tumour phylogenies As melanoma evolution was found to be dominated by CNAs, we estimated allele-specific CNA-based phylogenetic trees of spatiotemporally separated tumours and late disease ctDNA from each of 4 patients (CAS-D, CAS-B, CAS-G, CAS-C) whose melanomas progressed from near-diploid in early disease to hyperploid in late disease (Fig

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This excess led to reductive stress, which eventually contributed to heart failure in those specific animal models

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However, he emphasised that the current evidence is early and observational, and there is no national or international guidance requiring any change to how these medications are managed before scans