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For example, heroin is two times stronger than morphine, while fentanyl is 50 times stronger than heroin

To harness these biological effects, scientists developed GLP-1 receptor agonists (GLP-1 RAs) drugs that imitate GLP-1 by activating the same receptors

In Favor of Agonism While GIP serves as the primary incretin in healthy humans [43], its use as an anti-diabetic agent was initially discouraged by the finding that the insulinotropic action of GIP infusion is severely diminished in patients with T2D [8]

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