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It is cost-effective, widely available, well studied, and easier to justify than more expensive creatine forms that claim superior absorption without strong supporting evidence

Additionally, metformin not only influences glucose metabolism in TC cells, but also suppresses mitochondrial respiration, which adds to its antitumor effect [267]

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This formula is best taken on an empty stomach at least 20 minutes before meals

In the normoxic group, an aerator was used for continuous oxygenation to maintain dissolved oxygen above 6 mg/L

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