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Glutathione is hydrophilic and has a molecular weight above 300 Da both properties that restrict passive diffusion across the skins lipid barrier without a delivery vehicle

Its a safe and effective method, backed by studies

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Although anti-IGF-IR mAbs and IGF-IR inhibitors have potent anti-cancer effects in preclinical models, clinical trials of these agents are largely disappointing in unselected cancer patients

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Supporters cited a larger international literature than for several other peptides, while FDA staff said the material it could evaluate remained insufficient for the proposed uses