glp-1 and gip mechanism of action & Agonists | Obesity Diabetes Management | Harrison's updates (22nd Ed.) Tirzepatide Mechanism of Weight Loss

Quick Answer: Tirzepatide causes constipation in 12-26% of patients by slowing gastrointestinal motility through GLP-1 receptor activation, which delays transit time and increases water reabsorption from the colon

The name is the mechanism

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Pharmacologic strategies aimed at increasing arousal threshold may allow for improved airway stability and reduced respiratory events in selected patients