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This gene encodes 5 reductase-1, a steroidogenic enzyme that catalyzes production of steroids that repress ovarian follicle recruitment [31, 32] and of brain neurosteroids [33], so we hypothesized that its epigenetic regulation might underlie the altered reproductive characteristics

Weeks 5 to 8 (dose escalation to 0.6 mg) Nausea becomes more noticeable in some individuals as the dose doubles

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