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Before attributing symptoms to histamine intolerance, other conditions should be excluded according to UK guidelines, including: Food allergies (following BSACI guidance) Irritable bowel syndrome (NICE CG61) Coeliac disease (NICE NG20) Inflammatory bowel disease Red flags that warrant further investigation include unintentional weight loss, gastrointestinal bleeding, persistent vomiting, and iron-deficiency anaemia

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Uncontrolled hypertension should be stabilized before GLP-1 initiation

c , The structural transition of the sensor loop is documented by a Ramachandran plot analysis 77

Researchers also suspect that the profound hormonal and metabolic changes triggered by GLP-1 drugs may play a role