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Here, we show that impaired OGDHc activity (via ABHD11 inhibition) in human CD8 + lymphocytes has distinct effects from those observed in cancer cells, with the perturbed TCA cycle driving synthesis of unsaturated fatty acids, rather than the accumulation of 2-HG that inhibits 2-OGDDs

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After treatment with LDL-DHA nanoparticles, rat and human HCC cells underwent obvious lipid peroxidation, GSH depletion, and GPX4 inactivation before cell death, which ultimately proved to be ferroptosis 37

doi:10.1136/svn-2018-000143 Spence JD, Hankey GJ

This enzyme is responsible for regulating metabolic processes and fat storage within the body