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Conversely, in cells where NADPH-consuming reactions are active (e.g., fatty acid synthesis, antioxidant defense), the cytosolic concentration of NADPH decreases, while NADP + increases

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Epigenetics is defined as the modulation of gene expression without alterations to the underlying DNA sequence, mediated through reversible mechanisms such as DNA methylation, histone modifications, and regulation by non-coding RNAs (ncRNAs) 14

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These findings position the compound as a valuable research tool for investigating whether NNMT modulation influences age-associated metabolic changes in mammalian aging models

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