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These findings suggest that a GST tag is not an authentic TG2 substrate but instead is accidentally crosslinked by TG2 during cell lysate incubation

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It should be noted that although ROS play a central role in regulating oxygen homeostasis [537, 538], it was traditionally considered as harmful byproducts of aerobic metabolism but not key signaling molecules that regulate cellular processes until recent years [538, 539]

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Not yet in formal clinical trials