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Furthermore, the kidney can adjust the levels of essential players of nutrient homeostasis such as glucose and insulin (Krebs, 1963

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Ann Surg Oncol 16(3):614-22, 2009

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In Noonans syndrome genetic defects in the PTPN11 gene may affect this pathway and has been implicated in poor growth and poor response to GH therapy, although reports are conflicting (99, 100)