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People with a prior history of gastrointestinal problems and aged individuals are more likely to suffer from intense stomach cramps and severe diarrhoea after taking high doses of vitamin B. Most people are able to get enough vitamin B12 from their diets, however, occasionally when running low, supplements or B12 injections may be recommended

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Cell Death Differ 2006

Researchers dont think so, and the gene expression data backs them up

After being absorbed into the bloodstream, the peptide circulates everywhere, allowing it to interact with cells and trigger healing or protective processes in tissues far from the original point of administration