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Etiology, pathophysiology and biomarkers of interstitial cystitis/painful bladder syndrome

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SIRT3 lysine deacetylase inhibitors specifically target SIRT3 without affecting its structurally similar counterparts, SIRT1 and SIRT2 185,186

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NRF-1 and NRF-2 regulate nuclear and mitochondrial genes essential for various critical functions, such as oxidative phosphorylation (OXPHOS), electron transport chain complexes IV, mitochondrial DNA (mtDNA) transcription and replication, protein import and assembly, ion channel activity, molecular transport, and translation (47)