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DMT1 then mediates the transport of Fe 2+ from the endosome to the cell labile iron pool (LIP) ( Nuclear receptor coactivator 4 (NCOA4) binds to ferritin and mediates its delivery to autophagosomes ( 2+ participates in a series of physiological cell processes, including the generation of ROS through Fenton reactions, which further promotes lipid peroxidation ( 2.3 Ferroptosis defense mechanisms 2.3.1 System X c /GSH/GPX4 axis The System X c /GSH/GPX4 axis, DHODHubiquinol (CoQH 2 ) system, FSP1CoQ10 axis, GTP cyclohydrolase-1 (GCH1)tetrahydrobiopterin (BH4) axis, and sex hormones can inhibit ferroptosis, and the inhibition of related molecular pathways is an important strategy to induce ferroptosis in tumor cells ( c is a heterodimeric amino-acid transporter located on the cell membrane and consisting of two subunits: SLC3A2 and SLC7A11 (49)

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Lillys Phase III candidate retatrutide is a triple agonist

doi: 10.1016/j.ekir.2019.12.011

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