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Unlike dopaminergic or GABAergic compounds that cause receptor downregulation, c-Met receptor density doesnt decrease with prolonged agonist exposure in published models

One study noted that B12 supplements, along with folic acid, improved symptoms of neuropathy in patients treated with certain chemotherapy agents

Proc Natl Acad Sci U S A (1988) 85(13):488993.10.1073/pnas.85.13.4889 165 LaronZKlingerBJensenLTErsterB

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Bottom line: Its almost impossible to become toxic on vitamin B12 unless you have kidney issues

Therefore, while existing evidence supports low local toxicity, comprehensive in vitro and in vivo immunogenicity testing remains advisable prior to clinical translation [71, 191]