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The atomic coordinates for the atomic models of the ghrelin-GHSR-G i and ibutamoren-GHSR-G i complexes generated in this study have been deposited in the Protein Data Bank database under accession codes 7NA7 and 7NA8, respectively

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These fatty acids are particularly susceptible to oxidative damage, and their release from LDs can increase lipid peroxide levels within the cell, promoting ferroptotic cell death (78)

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By combining these mechanisms, tirzepatide provides effective glycemic control and has shown significant benefits for weight loss in clinical trials