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Structurally, the c-MET receptor is composed of a Semaphorin (SEMA) domain, a plexin-semaphorin-integrin (PSI) domain, and four consecutive immunoglobulin-plexin-transcription factors (IPT1-4) domains in the extracellular region, a single transmembrane helix (TM), and an intracellular KD (Fig

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