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29 Intriguingly, the intracellular consequences of tirzepatide binding at the GLP-1R seem to be peculiarly biased towards cyclic adenosine monophosphate generation, at the expense of -arrestin recruitment

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Sattar N, Neeland IJ, Dahlqvist Leinhard O, Fernndez Land L, Bray R, Linge J, Rodriguez A (2025) Tirzepatide and muscle composition changes in people with type 2 diabetes (SURPASS-3 MRI): a post-hoc analysis of a randomised, open-label, parallel-group, phase 3 trial