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In contrast to these natural actions and their biorhythms, GLP-1 receptor agonist drugs are synthesized to achieve much higher concentrations and last up to 10,000 times longer in the body than natural GLP-1, which is mostly produced by intestinal cells

while potentially a low-energy diet could be deleterious for a variety of reasons, in wild-type mice energy restriction induced by a low energy diet has similar impacts on lifespan as energy restriction induced by many feeding small meals of a normal diet 54

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Nearly half of those on the highest dose achieved at least 30% weight loss, which is the sort of result more often associated with bariatric surgery than with medication

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