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Some users do both: topical for the face, injectable for systemic benefits

Preclinical studies demonstrate that DSIP can alter pain threshold responses, with observed effects that are not reversed by opioid receptor antagonists such as naloxone, suggesting involvement of non-opioid or indirect neuromodulatory pathways [7]

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Withdrawal from opioids can make a person feel sleepy, but they may also have difficulty getting good quality sleep

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