Clinically meaningful interactions would not be expected with other sulfonylureas (e.g., glipizide, tolbutamide, and glimepiride) which, like glyburide, are primarily eliminated by CYP2C9 [see Warnings and Precautions]
The pivotal data come from randomized, placebo-controlled Phase 3 trials in the STEP program
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TRANSCEND Program Phase 3 Type 2 Diabetes Trials Study Design : Global Phase 3 randomized clinical trial program evaluating retatrutide in adults with type 2 diabetes
115336) (MIP-DILI) and the H2020 EU-ToxRisk Project (Grant No
Oral gavages are stressful, and there are likely differences in the uptake and metabolism between compounds administered orally (p.o.) and subcutaneously (s.c.), such as stimulation of gut hormones or altered first-pass metabolism
