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p-values calculated from limmas two-sided moderated t-test adjusted by Benjamini-Hochberg multiple testing correction

Yes, tirzepatide and metformin combination is effective for weight management in non-diabetic patients with insulin resistance or prediabetes

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Experts say products like berberine may have modest effects on blood sugar or appetite for some people, but they're not considered equivalent alternatives to medications like Ozempic or Zepbound