semaglutide and metformin together vs. adding metformin to semaglutide Is

References Zanker J, Sim M, Anderson K, Balogun S, Brennan-Olsen SL, Dent E, Duque G, Girgis CM, Grossmann M, Hayes A, Henwood T, Hirani V, Inderjeeth C, Iuliano S, Keogh J, Lewis JR, Lynch GS, Pasco JA, Phu S, Reijnierse EM, Russell N, Vlietstra L, Visvanathan R, Walker T, Waters DL, Yu S, Maier AB, Daly RM, Scott D

All three peptides show promising results in preclinical and early clinical studies, but further research is needed to confirm their long-term safety and efficacy

Expression of different pituitary phenotypes was quantified as the percentage of immunoreactive area per section of cultured primordia

Diabetes Obes Metab 18 , 258265, (2016)

The clinical evidence demonstrates that dual agonism can achieve therapeutic outcomes that substantially exceed those of single-pathway approaches, challenging fundamental assumptions about optimal treatment strategies for diabetes and obesity

Its not recommended with uncontrolled hypertension, significant cardiovascular disease, hyperthyroidism, glaucoma, pregnancy, or with MAOIs