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Genetics, gut microbiome composition, baseline GI health, concurrent medications, and individual amylin receptor sensitivity all contribute to this variation

Theres clear evidence of it affecting the somatotropic axis and GH secretion patterns, which makes sense given the tight link between deep sleep and growth hormone releaseafter all, most nocturnal GH secretion happens during slow-wave sleep

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245 Initially, during fasting, signaling pathways mediated by mTOR, insulin, and leptin are suppressed