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In addition, the analgesic effect of melatonin is mediated through activation of supraspinal sites, inhibition of spinal nociception, and modulation of various neurobiological systems, including GABAergic, opioid, and glutamatergic systems [65]

In the SKOV-3 and CAOV-3 cell lines, Ex-4 induces the activation of caspase-3/7 (cas-3/7), leading to the inhibition of tumor cell migration and induction of apoptosis [78]

In fact, once CRF was factored in, body weight failed to predict the risk of mortality

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