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One of the biggest reasons for delay is that endometriosis presents with vague symptoms reminiscent of menstrual pain, so it is sometimes misdiagnosed or ignored, according to Jocelyn J

It is a cofactor for lysyl oxidase, the enzyme that crosslinks new collagen and elastin into mature, stable matrix proteins

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Identification of cartilage microbial DNA signatures and associations with knee and hip osteoarthritis

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Its broader receptor activity underlies systemic side effects: pronounced nausea, vomiting, flushing, increased blood pressure, spontaneous and sometimes painful erections (priapism), and altered mood or libido